Our body produces various types of antibodies from the B-lymphocytes. These antibodies help to fight infection. The antibodies are IgA, IgD, IgE, IgM & IgG. Usually with infections the initial antibody to form is IgM which then switches to IgG, IgA or IgE. In patients with hyper IgM (HIM) syndrome, there is inability to switch IgM to IgG, IgA or IgE type. Thus patients are susceptible to infections.
↧